Staff Profiles

Currently Pharmaceutical Solutions has  a total staff of 5, of which there are 3 permanent Qualified Persons:
Ashley Ruffle, Managing Director & Consultant Qualified Person
Patricia Keegan, Consultant Qualified Person
Margaret Brown, Consultant Qualified Person
This enables the company to keep overhead costs to a realistic level whilst ensuring that back-up cover is available.  
Some clients also like the idea that the company is small and totally independent.


Ashley Ruffle
CSci CChem FRSC, Managing Director & Consultant Qualified Person

Over 35 years’  experience in Pharmaceuticals including, sterile products, tablets, capsules and softgels.  Extensive experience in both head of Production and head of Quality roles in the design, commissioning and day to day management of sterile facilities.  Other management responsibilities have included, resource-management, budgeting, hosting customer/ regulatory (MHRA, FDA) inspections and developing Quality Management Systems. Significant experience in auditing API suppliers, contract manufacturing / testing facilities on a global basis, including EU, USA, India & Japan. Eligible as QP for IMP and commercial products.

    Key Achievements
  • 32 years Pharma experience with equivalent experience of sterile product manufacture
  • Qualified Person with experience in the manufacture and packaging of all major product formats for both IMP and commercial use
  • Production and Quality Management experience gained directly within the pharmaceutical environment
  • Significant experience in preparing for and hosting regulatory and customer inspections
  • Experienced auditor of manufacturing facilities, service providers and material / component suppliers


Patricia Keegan
PhD CChem MRSC Consultant Qualified Person

Over 25 years' experience in Pharmaceuticals including granules, creams and ointments, pessaries, medicated sponges and sterile products. Significant experience in Laboratory Management gained as Head of QC/QA supporting a range of manufacturing activities. Additional responsibility for site Quality and Compliance including resourcing, budgeting, hosting regulatory (IMB, MHRA) and corporate inspections, development of the Quality Management System and Quality targets. Experience in liaising and auditing on a global basis in Europe, Switzerland & USA in the main. Qualified Person Status.

    Key Achievements
  • 21 years Pharma experience; 15 years as Site Head of QC/QA
  • Qualified Person with experience in the manufacture and packaging of a wide range of product formats
  • Experienced Quality manager with responsibility for developing the Quality Function and Quality Management Systems
  • Significant experience in preparing for and hosting audits and inspections
  • Experienced auditor of manufacturing facilities, service providers and material suppliers

Margaret Brown
MSC MRSC Consultant Qualified Person

Experienced Qualified Person and manager with a broad range of technical skills gained over 29 years in the manufacturing and development areas of pharmaceutical and FMCG. An analytical chemist (QC, analytical development/validation, stability), moving into facility management, validation (significant experience in CSV and cleaning), technology transfer, and post-marketed product maintenance, supplemented by a working knowledge of toxicology, medical device legislation and pharmacovigilance. Experienced in API manufacture and a wide range of formulated products – oral solid dose, oral liquids, sterile liquids, MDls, DPls, creams and ointments for global markets.

    Key Achievements
  • 29 years Pharma experience in QC and QA Management positions
  • Qualified Person eligible under 2001/82 and 2001/83, with experience in the manufacture and packaging of most product formats for IMP and commercial use
  • Experienced Quality manager with responsibility for developing and maintaining Quality Systems, preparing for and hosting audits and regulatory inspections
  • Experienced auditor of global (EU, USA, India, China, Japan) manufacturing facilities, service providers, material/component suppliers, API suppliers
Pharmaceutical Solutions Ltd

Qualified Person (QP) Services, EUQP, QPService, Pharmsol, Pharmaceutical Solutions Ltd.